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Total Synthesis of the Sesquiterpene (-)-Merrillianin
Isamu Shiina1, Takashi Iizumi1, Saori Taniguchi1
1Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Organic Letters
|December 31, 2023
Abstract:
The first total synthesis of (-)-merrillianin (1), which is a natural sesquiterpene with a tricyclic structure having a cyclopentane ring and five- and seven-membered lactone parts, is demonstrated. This asymmetric total synthesis enabled the absolute stereostructure determination of naturally occurring (-)-1.

