Impact of comorbidities and inflammatory markers on mortality of COVID-19 patients

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Azmat Karim1, Mohammad Shameem1, Anjana Talwar2

  • 1Department of TB and Respiratory Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Lung India : Official Organ of Indian Chest Society
|December 31, 2023
PubMed

Insights

This study identified key inflammatory markers and comorbidities impacting COVID-19 severity and mortality. Chronic kidney and coronary artery disease worsen prognosis, while ivermectin shows survival benefits.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Critical Care Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) poses a global health threat, with severity influenced by serologic indicators.
  • Preexisting conditions like respiratory and cardiovascular diseases increase adverse outcomes in COVID-19 patients.
  • Effective management of hospitalized COVID-19 patients is crucial for survival.

Purpose of the Study:

  • To investigate the influence of comorbidities and inflammatory markers on COVID-19 severity and mortality.
  • To identify specific risk factors and potential protective elements in hospitalized COVID-19 patients.

Main Methods:

  • Retrospective analysis of 101 hospitalized COVID-19 patients with comorbidities.
  • Data collected between April 2021 and April 2022.
  • Evaluation of inflammatory markers and comorbidities' impact on patient outcomes.

Main Results:

  • Elevated inflammatory markers (D-dimer, ferritin, IL-6) correlate with severe COVID-19.
  • Chronic kidney disease and coronary artery disease are significant risk factors for mortality (P < 0.001).
  • Ivermectin demonstrated a statistically significant survival advantage, while tocilizumab showed poor efficacy.

Conclusions:

  • D-dimer, ferritin, and IL-6 are key indicators of COVID-19 severity.
  • Chronic kidney and coronary artery diseases are mortality risk factors; tuberculosis may offer protection.
  • Ivermectin shows promise for improving COVID-19 survival rates.
Abstract

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