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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Adaptive Mechanisms in Cancer Cells02:53

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Regulation of Angiogenesis and Blood Supply01:24

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Jul 6, 2025

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
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Cancer stem cells and angiogenesis.

Yanru Yang1, Jingyu Guo2, Mingyang Li1

  • 1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, School of Basic Medicine and Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Pathology, Research and Practice
|December 31, 2023
PubMed
Summary

Targeting cancer stem cells and angiogenesis is crucial for effective cancer treatment. Anti-angiogenesis therapy offers a promising approach to inhibit tumor growth and metastasis.

Keywords:
AngiogenesisCancer stem cellsTargeted therapy

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cancer is a leading cause of death, with metastasis posing a significant challenge to treatment efficacy.
  • Metastatic cancer, driven by cancer stem cells, exhibits high mutation rates and drug resistance.
  • Current treatments struggle with widespread metastatic disease, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To provide an overview of molecular mechanisms linking cancer stem cells and angiogenesis.
  • To highlight the role of anti-angiogenesis therapy in combating metastatic cancer.
  • To explore the potential of targeting endothelial cells for cancer treatment.

Main Methods:

  • Review of molecular mechanisms.
  • Analysis of cancer stem cell behavior and metastasis.
  • Evaluation of anti-angiogenesis drug interactions with endothelial cells.

Main Results:

  • Cancer stem cells utilize blood and lymphatic vessels for metastasis, displaying drug resistance.
  • Endothelial cells are less prone to mutations, making them a more stable target.
  • Direct drug interaction with endothelial cells enhances therapeutic outcomes.

Conclusions:

  • Anti-angiogenesis therapy is pivotal in cancer treatment, particularly for metastatic disease.
  • Targeting the interaction between cancer stem cells and angiogenesis offers a promising therapeutic avenue.
  • Further research into these molecular mechanisms can lead to improved cancer therapies.