Related Experiment Video
Updated: Jul 6, 2025
03:37
Iatrogenic Injury Recapitulated: Electroexcision Technique for Urethral Stricture Modeling in Rats
Published on: October 11, 2024
355
Genomic Risk Factors for Urethral Stricture: A Systematic Review and Gene Network Analysis
Ilaha Isali1, Thomas R Wong1, Chen-Han Wilfred Wu2
1Department of Urology, Case Western Reserve University, Cleveland, OH.
Urology
|December 31, 2023
Summary
This study identified key gene expression differences in urethral stricture patients, highlighting pathways like PI3 kinase and TGF-β1/SMAD signaling. These findings offer insights into urethral stricture
Area of Science:
- Urology
- Genetics
- Molecular Biology
Background:
- Urethral stricture is a condition with limited understanding of its underlying genetic factors.
- Identifying genetic variations can improve diagnosis and treatment strategies for urethral stricture.
Approach:
- A systematic review of studies published between 2000 and 2023 was conducted.
- Molecular techniques were used to analyze gene expression in blood, urine, and tissue samples from patients with urethral stricture and healthy controls.
- Gene network and pathway analyses were performed using Cytoscape software.
Key Points:
- CXCR3 and NOS2 gene expressions were downregulated in urethral tissue.
- TGFB1, UPK3A, and CTGF gene expressions were upregulated in plasma, urine, and tissue samples.
- Significant pathways identified include phosphoinositide 3-kinase (PI3 kinase) and transforming growth factor beta 1/suppressor of mothers against decapentaplegic (TGF-β1/SMAD) signaling.
Conclusions:
- This review identified specific gene expression variations linked to urethral stricture.
- The findings highlight the involvement of PI3 kinase and TGF-β1/SMAD signaling pathways.
- These insights may guide future research and therapeutic interventions for urethral stricture.
Related Concept Videos
01:30Esophageal Strictures-I: Introduction
102
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
102
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:11Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
01:38Nucleotide Excision Repair
3.5K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.5K