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Related Experiment Video

Updated: Jul 6, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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ViCEKb: Vitiligo-linked Chemical Exposome Knowledgebase.

Nikhil Chivukula1, Kundhanathan Ramesh2, Ajay Subbaroyan1

  • 1The Institute of Mathematical Sciences (IMSc), Chennai, India; Homi Bhabha National Institute (HBNI), Mumbai, India.

The Science of the Total Environment
|December 31, 2023
PubMed
Summary

Environmental chemicals can trigger vitiligo. We created the Vitiligo-linked Chemical Exposome Knowledgebase (ViCEKb) with 113 chemicals, many found in consumer products, to better understand vitiligo causes.

Keywords:
Autoimmune diseasesChemical ExposomeCheminformaticsKnowledgebasesSystems biologyVitiligo

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Area of Science:

  • Dermatology and Toxicology
  • Environmental Health
  • Cheminformatics

Background:

  • Vitiligo pathogenesis involves genetic and environmental factors, but environmental triggers are poorly understood.
  • Existing research lacks a centralized resource for identifying chemicals linked to vitiligo.
  • Understanding chemical exposures is crucial for deciphering vitiligo etiology.

Purpose of the Study:

  • To establish the first comprehensive knowledgebase of vitiligo-triggering chemicals, named ViCEKb.
  • To systematically curate and compile known chemical triggers of vitiligo from published literature.
  • To facilitate research into the environmental causes of vitiligo.

Main Methods:

  • Systematic manual curation of scientific literature to identify vitiligo-associated chemicals.
  • Compilation of 113 unique chemical triggers into the ViCEKb database.
  • Cheminformatics and transcriptomics analyses to explore chemical properties and biological impacts.

Main Results:

  • ViCEKb contains 113 unique vitiligo-triggering chemicals, categorized by evidence and exposure source.
  • Identified chemicals like Propyl gallate and Flutamide are common in consumer products and medications but lack skin sensitization regulation.
  • Cheminformatics analysis revealed unique chemical scaffolds in ViCEKb compared to regulatory lists, with some unregulated chemicals showing high evidence.
  • Transcriptomics data indicated common biological pathways affected by ViCEKb chemicals.

Conclusions:

  • ViCEKb is a valuable resource for understanding the chemical exposome in vitiligo.
  • The findings highlight the need for regulation of certain chemicals found in consumer products and medications.
  • This knowledgebase can advance research into vitiligo's complex etiology and environmental triggers.