Causal association between serum 25-hydroxyvitamin D levels and right ventricular structure and function: A Mendelian...

Area of Science:

• Cardiovascular Health
• Endocrinology
• Genetics

Background:

• Vitamin D deficiency is associated with cardiovascular diseases.
• The specific impact of vitamin D on right ventricular function is not well understood.

Purpose of the Study:

• To investigate the potential causal relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and right ventricular structure and function.
• To clarify the role of vitamin D in maintaining healthy right ventricular parameters.

Main Methods:

• Employed Mendelian randomization (MR) analysis.
• Utilized genetic instrumental variables from genome-wide association studies (GWAS) for 25(OH)D levels.
• Analyzed summary statistics for right ventricular parameters (end diastolic volume, end systolic volume, stroke volume, ejection fraction) from GWAS datasets.

Main Results:

• No significant causal association was found between serum 25(OH)D levels and right ventricular end diastolic volume (p=0.063).
• No significant causal association was found between serum 25(OH)D levels and right ventricular end systolic volume (p=0.105).
• No significant causal association was found between serum 25(OH)D levels and right ventricular stroke volume (p=0.099) or ejection fraction (p=0.928).

Conclusions:

• The study found no substantial evidence to support a causal link between serum 25(OH)D levels and right ventricular structure or function.
• Serum 25(OH)D levels may not directly influence key right ventricular parameters.