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Published on: March 11, 2017
An Overview of the Role of Peroxisome Proliferator-activated Receptors in Liver Diseases
Zahra Changizi1, Forough Kajbaf2, Azam Moslehi1
1Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
Abstract:
Peroxisome proliferator-activated receptors (PPARs) are a superfamily of nuclear transcription receptors, consisting of PPARα, PPARγ, and PPARβ/δ, which are highly expressed in the liver. They control and modulate the expression of a large number of genes involved in metabolism and energy homeostasis, oxidative stress, inflammation, and even apoptosis in the liver. Therefore, they have critical roles in the pathophysiology of hepatic diseases. This review provides a general insight into the role of PPARs in liver diseases and some of their agonists in the clinic.
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