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Published on: September 20, 2024
Amantadine induced interface fluid formation after LASIK. A case report
Alexander Altman1, Mustafa Jaffry1, Mohammed H Dastjerdi1
1Department of Ophthalmology, Rutgers New Jersey Medical School, USA.
Purpose:
To describe a case of bilateral interface fluid formation 2 years after laser-assisted in situ keratomileusis (LASIK) surgery caused by the side effect of amantadine.
Observations:
A 47-year-old male patient with a history of Parkinson's disease treated with amantadine who had uneventful LASIK surgery in both eyes 2 years ago, presented with a decline in vision over the past 6 weeks. Results: Best corrected vision was 20/200 and 20/400 in the right and left eye respectively. Intraocular pressures were measured within the normal range. Biomicroscopic exam showed bilateral corneal edema. Anterior segment optical coherence tomography (AS-OCT) revealed fluid accumulation within the LASIK flap interface in both corneas. The patient's corneal edema and fluid in the interface began to gradually resolve, and vision improved 2 weeks after discontinuing amantadine.
Conclusions And Importance:
Although there is no previous report, it is possible that amantadine may cause interface fluid formation in patients with LASIK surgery.
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