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A pulse generating and data recording system based on the microcomputer PDP 11/23.

D Hof

    Computer Methods and Programs in Biomedicine
    |December 1, 1986
    PubMed
    Summary
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    This study presents a versatile voltage-clamp measuring system for patch-clamp and other electrophysiology experiments. The system utilizes readily available hardware and software, ensuring broad applicability and ease of implementation.

    Area of Science:

    • Electrophysiology
    • Biophysical Measurement Techniques
    • Neuroscience Instrumentation

    Background:

    • Voltage-clamp techniques are crucial for studying ion channel function.
    • Existing electrophysiology setups can be complex and expensive.
    • A need exists for accessible and adaptable measurement systems.

    Purpose of the Study:

    • To develop a widely applicable measuring system for voltage-clamp experiments.
    • To create a system compatible with patch-clamp electrophysiology.
    • To leverage commercial components for cost-effectiveness and ease of use.

    Main Methods:

    • The system is primarily built using commercially available hardware and software.
    • Analog signal interfacing is performed via the microcomputer's front panel.

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  • Synchronization is achieved using unused digital-to-analog converter bits during direct memory access transfer.

    • Main Results:

    • A functional measuring system for voltage-clamp experiments was successfully implemented.
    • The system demonstrates suitability for various voltage-clamp applications, including patch-clamp.
    • The design integrates standard components for efficient operation.

    Conclusions:

    • The presented system offers a versatile and accessible solution for electrophysiology research.
    • Commercial component integration simplifies setup and enhances applicability.
    • The synchronization method ensures precise control and data acquisition.