Overlap of Primary Membranous Nephropathy, IgA Nephropathy, and Diabetic Nephropathy: A Case Report

The coexistence of primary membranous nephropathy (PMN), immunoglobulin A nephropathy (IgAN), and diabetic nephropathy (DN) in the same patient has been a subject of clinical and pathological investigation, yielding inconclusive results. The limited availability of cases and resource materials has hindered a comprehensive understanding of this phenomenon. We present the case of a 70-year-old Saudi Arabian man diagnosed with type 2 diabetes mellitus and nephrotic syndrome. A kidney biopsy revealed the coexistence of PMN, IgAN, and DN. The patient presented with an unusual and rare combination of PMN, IgAN, and DN. To address his condition, the patient consented to rituximab therapy and planned follow-up with the kidney transplant team. However, before the first dose of rituximab could be administered, the patient experienced severe septic shock secondary to pneumonia, which tragically led to his demise. The simultaneous occurrence of PMN, IgAN, and DN represents a rare and scarcely documented condition. The purpose of this article is to report this exceptional case, emphasizing the significance of further research to deepen the understanding of the underlying pathology behind these concurrent renal disorders. This report aims to shed light on the complexities of managing such complex cases and advancing therapeutic approaches in the future.