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Updated: Jul 6, 2025
08:59
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
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Microphysiological systems as reliable drug discovery and evaluation tools: Evolution from innovation to maturity
Hye-Ran Moon1, Nishanth Surianarayanan1, Tarun Singh1
1School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
Biomicrofluidics
|January 1, 2024
Summary
Microphysiological systems (MPSs), or organ-on-chip technology, offer promising in vitro models for drug discovery. Overcoming standardization and practical challenges is key to their wider adoption in pharmaceutical research.
Area of Science:
- Biotechnology
- Pharmacology
- Biomedical Engineering
Background:
- Microphysiological systems (MPSs), also known as organ-on-chip, mimic in vivo cellular microenvironments on in vitro platforms.
- These microfluidic devices are designed for reliable drug discovery and regulatory evaluation.
Purpose of the Study:
- To review the current and potential applications of MPS platforms in drug discovery.
- To identify opportunities and challenges for broader MPS adoption in pharmaceutical research and regulatory evaluation.
Main Methods:
- Literature review of MPS applications across key drug discovery stages.
- Analysis of factors hindering MPS adoption in industry.
Main Results:
- MPS adoption in drug discovery lags due to a lack of standardization, reproducibility, and practical implementation challenges.
- MPS platforms hold potential to improve efficiency in drug discovery, screening, and approval.
Conclusions:
- Addressing standardization and practical issues is crucial for realizing the full potential of MPS in drug discovery.
- Wider adoption of MPS can lead to more efficient and cost-effective development of innovative drugs.
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