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Related Experiment Video

Updated: Jul 6, 2025

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation
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Stillbirth risk factors, causes and evaluation.

Christy Gandhi1, Jessica Page2

  • 1Columbia University Irving Medical Center, United States.

Seminars in Perinatology
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Stillbirth affects 5.73 per 1,000 US births, with many cases unexplained. Comprehensive evaluations are crucial for identifying causes and reducing stillbirth rates.

Keywords:
fetal anomaliesplacental pathologystillbirth

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Area of Science:

  • Perinatal Medicine
  • Obstetrics
  • Public Health

Background:

  • Stillbirth affects 5.73 per 1,000 births in the US, exceeding rates in other high-resource nations.
  • Identified risk factors include demographic and medical characteristics, alongside various pathophysiologic mechanisms.
  • A significant challenge in stillbirth prevention is the high proportion of unexplained cases, hindering effective risk stratification.

Purpose of the Study:

  • To highlight the impact of stillbirth in the United States.
  • To emphasize the challenge posed by unexplained stillbirths.
  • To advocate for comprehensive stillbirth evaluations.

Main Methods:

  • Review of existing literature and data on stillbirth rates and risk factors.
  • Analysis of findings from a large, multi-center study on stillbirth evaluations.
  • Discussion of the implications of unexplained stillbirths on public health.

Main Results:

  • The United States stillbirth rate is 5.73 per 1,000 births.
  • Approximately 24% of stillbirths remain unexplained even after thorough evaluation in study settings.
  • Real-world data on unexplained stillbirths outside of rigorous studies are limited.

Conclusions:

  • A substantial number of stillbirths remain unexplained, complicating prevention efforts.
  • Improving cause-of-death identification through comprehensive, evidence-based evaluations is essential.
  • Further research and standardized protocols are needed to address unexplained stillbirths.