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Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
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Severe night sweating treated by oxybutynin.

Leonor Dias1,2, Celine Martinot3, Garance Vaillant1

  • 1Sleep Clinic, Pitie-Salpetriere University Hospital, Assistance Publique-Hôpitaux de Paris-Sorbonne, Paris, France.

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|January 2, 2024
PubMed
Summary

Severe primary sleep hyperhidrosis, characterized by disruptive nocturnal sweating, was effectively treated with oxybutynin. This anticholinergic medication provided a resolution for a long-standing case, suggesting a potential new treatment avenue.

Keywords:
diaphoresishyperhidrosisoxybutyninsleep-related sweatingsweats

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Area of Science:

  • Sleep Medicine
  • Dermatology
  • Pharmacology

Background:

  • Sleep hyperhidrosis involves profuse nighttime sweating disrupting sleep.
  • Its exact mechanism is unknown, with potential links to thermoregulation, menopausal hot flushes, or other medical conditions.

Observation:

  • A case study details a woman experiencing severe primary sleep hyperhidrosis nightly for 23 years.
  • Sweat characteristics (ammoniacal odor, cold sensation) suggested a mechanism beyond thermoregulation, possibly related to emotional sweating.

Findings:

  • Brief treatment with oxybutynin, an anticholinergic medication, completely resolved the patient's severe sleep hyperhidrosis.
  • The treatment demonstrated excellent efficacy with minimal reported side effects.

Implications:

  • Oxybutynin offers a potential therapeutic option for severe primary sleep hyperhidrosis.
  • This finding may benefit patients suffering from significant nighttime sweating and sleep disturbance.