Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

2.0K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.0K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Bone Remodeling01:40

Bone Remodeling

38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Gross Anatomy of Bone01:17

Gross Anatomy of Bone

5.2K
The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in...
5.2K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

4.5K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of chronic cholecalciferol supplementation and vitamin D status on risk of post-vaccination SARS-CoV-2 breakthrough infection.

Endocrine·2026
Same author

Osteometabolic complications in patients with secreting pituitary adenomas: Is there an impact of gender?

Pituitary·2026
Same author

Current application and future directions for the sarcopenic obesity Global Leadership Initiative (SOGLI) diagnostic algorithm.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Neuroendocrine and neural control of bone mass in health and disease.

The Journal of clinical investigation·2026
Same author

Consensus on acromegaly complications: an update.

Pituitary·2026
Same author

Acromegaly complications: an update.

The Journal of clinical endocrinology and metabolism·2026
Same journal

Long-Term Trends in Thyroid Cancer Incidence and Mortality in Korea: Analysis of Korean National Data.

Endocrinology and metabolism (Seoul, Korea)·2026
Same journal

Impact of Health Behaviors on Cardiovascular Risk in Thyroid Cancer Survivors according to Metastasis: A Nationwide Cohort Study.

Endocrinology and metabolism (Seoul, Korea)·2026
Same journal

Levothyroxine Discontinuation: The Potential Role of Excess Iodine Exposure.

Endocrinology and metabolism (Seoul, Korea)·2026
Same journal

From Risk Categories to Risk-Adapted Care: Comparing the 2025 American Thyroid Association and 2024 Korean Thyroid Association Risk Stratification Systems in Differentiated Thyroid Cancer.

Endocrinology and metabolism (Seoul, Korea)·2026
Same journal

Update on Glucocorticoid-Induced Osteoporosis: Emerging Therapeutic Strategies.

Endocrinology and metabolism (Seoul, Korea)·2026
Same journal

Contemporary Type 2 Diabetes Guidelines: Converging Evidence, Diverging Strategies, and the Position of the Korean Diabetes Association Framework.

Endocrinology and metabolism (Seoul, Korea)·2026
See all related articles

Related Experiment Video

Updated: Jul 6, 2025

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

83.8K

Acromegaly and Bone: An Update.

Andrea Giustina1

  • 1Institute of Endocrine and Metabolic Sciences, San Raffaele Hospital, San Raffaele Vita Salute University, Milan, Italy.

Endocrinology and Metabolism (Seoul, Korea)
|January 2, 2024
PubMed
Summary
This summary is machine-generated.

Acromegaly significantly increases vertebral fracture risk, a finding confirmed by numerous studies since 2006. This review integrates new research on the pathophysiology and treatment of this important comorbidity.

Keywords:
AcromegalyBone densityBone qualityGrowth hormoneInsulin-like growth factor IMorphometryVertebral fractures

More Related Videos

Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

8.2K
Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

12.0K

Related Experiment Videos

Last Updated: Jul 6, 2025

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

83.8K
Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

8.2K
Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

12.0K

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Clinical Research

Background:

  • Acromegaly, a disorder caused by excess growth hormone, has been linked to an increased risk of vertebral fractures since 2006.
  • This association has been substantiated by extensive cross-sectional and prospective research, highlighting its clinical significance.

Approach:

  • This narrative review synthesizes recent advancements in the understanding of acromegaly and bone health.
  • It integrates novel findings on pathophysiology and treatment with foundational observations.

Key Points:

  • The link between acromegaly and vertebral fractures is a significant comorbidity.
  • Recent research has expanded knowledge regarding the mechanisms underlying this relationship.
  • New therapeutic strategies are emerging for managing bone health in acromegaly patients.

Conclusions:

  • The field of acromegaly and bone health has evolved from clinical observations to mechanistic insights.
  • Updated understanding facilitates improved prevention and treatment strategies for vertebral fractures in acromegaly.