Related Experiment Video

Updated: Jul 6, 2025

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

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Advances in the regulatory mechanisms of mTOR in necroptosis

Yawen Xie1, Guoyu Zhao1, Xianli Lei1

  • 1Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Frontiers in Immunology
|January 2, 2024
PubMed

Insights

The mammalian target of rapamycin (mTOR) influences programmed cell death, specifically necroptosis, by regulating key proteins and reactive oxygen species. Further research is needed to fully understand mTOR

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Programmed cell death (PCD) is crucial for tissue homeostasis and removing aberrant cells.
  • Necroptosis, a regulated form of PCD, involves receptor-interacting serine-threonine kinases (RIPKs) and mixed lineage kinase domain-like protein (MLKL).
  • The mammalian target of rapamycin (mTOR) pathway is a central regulator of cellular processes, including gene expression, metabolism, and cell death.

Purpose of the Study:

  • To review the mechanisms of mTOR activation and necroptosis.
  • To elucidate the signaling pathways through which mTOR regulates necroptosis.
  • To highlight the bifacial role of mTOR in necroptosis and its therapeutic implications.

Main Methods:

  • Literature review of existing research on mTOR signaling and necroptosis.
  • Analysis of molecular mechanisms linking mTOR to RIPKs, autophagy, and reactive oxygen species (ROS).
  • Synthesis of current knowledge on mTOR's role in regulating necroptosis pathways.

Main Results:

  • mTOR directly regulates RIPKs, key components of the necroptosis machinery.
  • mTOR indirectly controls RIPK levels and interactions via autophagy.
  • mTOR modulates necroptosis by influencing reactive oxygen species (ROS) production under oxidative stress.

Conclusions:

  • mTOR plays a complex, potentially dual role in regulating necroptosis.
  • Understanding mTOR's intricate regulation of necroptosis is vital for developing targeted therapies.
  • Further investigation is required to fully delineate the molecular mechanisms of mTOR's influence on necroptosis.
Keywords:
RIPKROSautophagymTORnecroptosis

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