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Updated: Jul 6, 2025

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

Rapid predictive dosimetry for radioembolization.

Yung Hsiang Kao¹

¹Department of Nuclear Medicine, The Royal Melbourne Hospital, Victoria, Australia.

Asia Oceania Journal of Nuclear Medicine & Biology

|January 2, 2024

Summary

This summary is machine-generated.

A new rapid predictive schema for liver radioembolisation offers a time-efficient alternative to complex dosimetry. This method prioritizes speed over absolute accuracy, suitable for resource-limited settings.

Keywords:

Predictive dosimetry Radioembolization Selective internal radiation therapy Theranostics Yttrium-90 microspheres Radionuclide therapy

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Area of Science:

Medical Physics
Radiology
Nuclear Medicine

Background:

Clinical practice demands efficient predictive dosimetry for liver radioembolisation.
Current methods can be time-consuming and costly, posing challenges for routine workflows.

Purpose of the Study:

To develop a rapid predictive schema for liver radioembolisation.
To provide a time- and cost-efficient dosimetry method for busy clinical practices.

Main Methods:

Adapted a schema from the Medical Internal Radiation Dose (MIRD) Partition Model.
Designed for completion within minutes, applicable to beta-emitting radiomicrospheres.

Main Results:

The schema achieves significant time efficiency for predictive dosimetry.
It offers a viable alternative where advanced software or complex dosimetry is unfeasible.

Conclusions:

This rapid schema enhances efficiency in predictive dosimetry for liver radioembolisation.
Users must be aware of potential sampling errors and revert to standard methods if significant errors are suspected.