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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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To Investigate Growth Factor Receptor Targets and Generate Cancer Targeting Inhibitors

Debroop Basu1, Riya Pal2, Maitrayee Sarkar1

  • 1Cell and Developmental Biology Special, Department of Zoology, University of Kalyani, Kalyani, Nadia, 741235, India.

Current Topics in Medicinal Chemistry
|January 2, 2024
PubMed

Insights

Receptor tyrosine kinases (RTKs) are crucial for cell growth but their dysregulation drives cancer. This review examines RTK signaling pathways and their therapeutic targeting in cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Receptor tyrosine kinases (RTKs) regulate vital cellular processes like proliferation and division.
  • Dysregulation of RTK signaling is implicated in the initiation and progression of various cancers.
  • Specific RTK subfamilies (EGFR, FGFR, PDGFR, VEGFR, HGFR) are frequently altered in tumors.

Conclusions:

  • Targeting RTKs is a critical strategy in cancer therapy.
  • Understanding RTK signaling is essential for developing effective cancer treatments.
  • Further clinical evaluation of RTK inhibitors is warranted.
Keywords:
Cancer treatment.EGFRFGFRHGFRPDGFRPotential inhibitorsRTKVEGFR

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