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Do patients with bipolar disorders have an increased risk of myocardial infarction? A systematic review and

C-Y Jiang1, X-Y Zhu, J-L Wu

  • 1Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Zhejiang Province, China. 15857146998@163.com.

European Review for Medical and Pharmacological Sciences
|January 2, 2024
PubMed

Insights

This meta-analysis found no increased risk of myocardial infarction (MI) in patients with bipolar disorder (BD). Further research is needed to clarify the association due to study limitations.

Area of Science:

  • Cardiology
  • Psychiatry
  • Epidemiology

Background:

  • Bipolar disorder (BD) may alter cardiovascular disease risk, but the link to myocardial infarction (MI) requires clarification.
  • This study systematically reviews evidence on the association between BD and subsequent MI risk.

Approach:

  • A comprehensive literature search was conducted across major databases (PubMed, Embase, Scopus, CENTRAL, Web of Science) up to August 2023.
  • Random-effects meta-analysis was employed to calculate the pooled odds ratio (OR) for MI in BD patients.

Key Points:

  • Six studies encompassing 19,862,894 individuals (46,627 with BD) were analyzed.
  • Meta-analysis indicated no significantly higher risk of MI in BD patients compared to the general population (OR: 1.36, 95% CI: 0.99, 1.86).
  • The analysis exhibited substantial heterogeneity (I2=86%), with no significant publication bias detected.

Conclusions:

  • Current evidence does not support an association between bipolar disorder and an increased subsequent risk of myocardial infarction.
  • High heterogeneity and insufficient adjustment for confounders in existing studies highlight the need for future research.
Abstract

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