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Recurrent Rhombencephalitis Associated With Anti-GAD65 Antibody

Alexandre R Alferes1, Inês Carvalho1, Andre Jorge1

  • 1From the Neurology Department (A.R.A., I.C., A.J., J.M.L., S.B.), Coimbra Hospital and University Centre (CHUC); and Faculty of Medicine of the University of Coimbra (J.M.L., S.B.), Portugal.

Neurology
|January 2, 2024
PubMed

Insights

A 66-year-old man experienced vision and coordination problems. Brain MRI showed abnormalities in key areas of the brainstem and cerebellum, indicating potential neurological damage.

Area of Science:

  • Neurology
  • Neuroimaging
  • Cerebellar Diseases

Background:

  • Diplopia, ataxia, and loss of dexterity are significant neurological symptoms.
  • Cerebellar and brainstem involvement can lead to complex motor and sensory deficits.

Observation:

  • A 66-year-old male presented with acute onset of diplopia (double vision).
  • The patient also exhibited ataxia (impaired coordination) and loss of fine motor control in his right hand.

Findings:

  • Brain Magnetic Resonance Imaging (MRI) revealed T2-hyperintensities.
  • These hyperintensities were localized to the right cerebellar peduncles, pons, medulla, and cerebellum.
  • The MRI findings suggest inflammation or ischemic changes in these critical neurological structures.

Implications:

  • These findings highlight the importance of detailed neuroimaging in diagnosing neurological disorders.
  • Early identification of cerebellar and brainstem lesions is crucial for timely intervention.
  • Further investigation is warranted to determine the underlying cause of these T2-hyperintensities.

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