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Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
Published on: January 26, 2013
Does TFAP2C govern conflicting cell fates in mouse preimplantation embryos?
Chad S Driscoll1, Jaehwan Kim1,2, Mohamed Ashry1
1Department of Animal Science, Developmental Epigenetics Laboratory, Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan, USA.
Abstract:
Transcription factor AP2 gamma (TFAP2C) is a well-established regulator of the trophoblast lineage in mice and humans, but a handful of studies indicate that TFAP2C may play an important role in pluripotency. Here, we hypothesize and provide new evidence that TFAP2C functions as an activator of trophoblast and pluripotency genes during preimplantation embryo development.
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