GATA-3-dependent Gene Transcription is Impaired upon HDAC Inhibition.

Xiangrong Geng1, Chenguang Wang1, Suhaib Abdelrahman1

  • 1Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, Michigan.

Summary

Histone deacetylase inhibitors (HDACi) reprogram T-cell lymphoma by increasing GATA-3 acetylation, impairing its DNA binding and gene regulation. This mechanism offers new therapeutic strategies for GATA-3-driven lymphomas.

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