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Aptamer-Magnetic Nanoparticle Complexes for Powerful Biosensing: A Comprehensive Review.
Farag M A Altalbawy1,2, Eyhab Ali3, Mohammed N Fenjan4
1Department of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia.
Critical Reviews in Analytical Chemistry
|January 2, 2024
Summary
Magnetic nanomaterial-aptamer conjugates offer sensitive and selective disease diagnosis. These advanced probes enable efficient quantification and analysis of biomolecules in complex samples, improving biosensor performance.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Analytical Chemistry
Background:
- Selective and sensitive disease diagnosis is crucial for early treatment.
- Magnetic nanomaterial-aptamers are emerging as advanced probes for biomedical analysis.
- Existing probes face challenges in complex sample analysis and quantification.
Purpose of the Study:
- To review the fabrication of novel aptasensors using magnetic nanomaterials.
- To explore diverse applications of these magnetic nanomaterial-aptamer probes.
- To discuss research gaps and limitations in this field.
Main Methods:
- Integration of magnetic nanomaterials with aptamers for enhanced biosensor performance.
- Utilizing superparamagnetic properties for separation and functional groups for immobilization.
- Leveraging aptamer's selectivity and stability for high-potential recognition.
Main Results:
- Magnetic nanomaterial-aptamer probes offer efficient quantification and purification in complex samples.
- These probes facilitate low sample volume, fast diagnosis, and high repeatability.
- Applications include detection of cancer biomarkers, proteins, drugs, bacteria, and nucleosides.
Conclusions:
- Aptasensors based on magnetic nanomaterials represent a significant advancement in biosensing.
- These probes show great potential for various biomedical quantification applications.
- Further research is needed to address existing gaps and limitations.
