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Metal-organic framework-based platforms for implantation applications: recent advances and challenges
Yifan Liu1,2, Shuteng Wang1,2, Chunhua Quan3
1State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. leiwang@ciac.ac.cn.
Journal of Materials Chemistry. B
|January 2, 2024
Summary
Metal-organic frameworks (MOFs) show promise as implantable materials for pain relief and tissue engineering. This review covers recent advances in MOF applications for orthopedic, cardiovascular, and neural implants, alongside biochemical sensing.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Medical Engineering
Background:
- Minimally invasive technologies drive demand for advanced implantable materials.
- Metal-organic frameworks (MOFs) offer unique properties like large surface area and tunable structures for biomedical applications.
Purpose of the Study:
- To review recent advancements in MOF-based materials for various implantable applications.
- To correlate MOF structural features with their performance in orthopedic, cardiovascular, and neural implantation.
- To discuss challenges and future directions for MOFs in interventional medicine.
Main Methods:
- Literature review of recent studies on MOF applications in implant interventional fields.
- Analysis of structure-property relationships of MOFs for specific implantation scenarios.
- Synthesis of current progress and future outlook in MOF-based implant technology.
Main Results:
- MOFs and their hybrids are emerging as versatile platforms for implant interventional materials.
- Significant progress has been made in orthopedic, cardiovascular, and neural tissue engineering applications.
- MOFs demonstrate potential in biochemical sensing for diagnostic purposes.
Conclusions:
- MOF-based materials hold considerable potential for improving implant interventional therapies.
- Further research is needed to overcome current challenges and fully realize their clinical benefits.
- Tailoring MOF structures is key to optimizing performance in diverse biomedical applications.
