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Engineering Strategies to Modulate the Gut Microbiome and Immune System
Kai Han1,2,3, Jin Xu1,3, Fang Xie1,3
1Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI.
Journal of Immunology (Baltimore, Md. : 1950)
|January 2, 2024
Summary
Emerging oral therapies can reshape the gut microbiome to restore immune function. These strategies offer new ways to treat diseases like cancer, autoimmune disorders, and allergies by targeting the gut microbiota.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- The gut microbiota is a complex ecosystem crucial for immune system function.
- Microbial imbalances (dysbiosis) are linked to various diseases, necessitating novel therapeutic interventions.
- Targeting the gut microbiome is a promising strategy for restoring immune homeostasis.
Conclusions:
- Oral delivery systems represent a significant advancement in microbiome-targeted therapeutics.
- Harnessing the gut microbiota-immune system interplay can lead to novel treatments.
- These strategies hold potential for managing cancer, autoimmune disorders, and allergies.
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