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Recent advances of engineered oncolytic viruses-based combination therapy for liver cancer

Junhe Zhang1,2,3, Yunxi Xiao4, Jie Zhang5

  • 1Institutes of Health Central Plains, Xinxiang Medical University, No. 601 Jinsui Road, Xinxiang, 453003, Henan Province, China. zjh@xxmu.edu.cn.

Journal of Translational Medicine
|January 3, 2024
PubMed

Insights

Genetically engineered oncolytic viruses (OVs) show promise for liver cancer gene therapy by selectively targeting and killing tumor cells. This review explores OV applications, target genes, and combination therapy strategies for improved liver cancer treatment.

Area of Science:

  • Oncology
  • Virology
  • Gene Therapy

Background:

  • Liver cancer poses a significant global health threat.
  • Gene therapy is a promising avenue for liver cancer treatment.
  • Oncolytic viruses (OVs) offer targeted tumor cell destruction.

Purpose of the Study:

  • To review genetically engineered oncolytic viruses (OVs) for liver cancer gene therapy.
  • To focus on OV applications and target genes in liver cancer treatment.
  • To identify challenges and solutions in OV-based combination therapy for liver cancer.

Main Methods:

  • Review of current research on genetically engineered oncolytic viruses.
  • Analysis of OV applications and target genes in liver cancer.
  • Examination of combination therapy strategies and their challenges.

Main Results:

  • Genetically engineered OVs demonstrate specificity for tumor cells, reducing impact on normal cells.
  • OVs have shown effectiveness and safety in preclinical and clinical studies for various tumors.
  • The review synthesizes current knowledge on OVs in liver cancer gene therapy.

Conclusions:

  • Genetically engineered OVs represent a viable strategy for liver cancer gene therapy.
  • Understanding OV mechanisms and combination therapies can enhance treatment outcomes.
  • This review provides insights for advancing OV-based liver cancer treatment.
Keywords:
Gene therapyLiver cancerOncolytic virusTargeted therapy

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