Multiple hydrogen bonding driven supramolecular architectures and their biomedical applications.

Area of Science:

• Supramolecular Chemistry
• Materials Science
• Biomedical Engineering

Background:

• Hydrogen bonding is a key interaction for molecular self-assembly.
• Challenges remain in hydrogen-bonding-based supramolecular polymers, including tautomerism and structural versatility.
• This review focuses on advancements and applications of multiple hydrogen bonding in supramolecular chemistry.

Purpose of the Study:

• To provide insights into emerging supramolecular architectures driven by multiple hydrogen bonds.
• To highlight applications in diverse fields, particularly biomedical materials.
• To discuss current challenges and future perspectives in the field.

Main Methods:

• Review of selected examples showcasing multiple hydrogen bonding driven supramolecular architectures.
• Focus on specific applications including chiral assemblies, stimuli-responsive materials, and organic frameworks.
• Detailed examination of biomedical applications such as drug delivery, DNA detection, tissue engineering, and gene delivery.

Main Results:

• Multiple hydrogen bonding enables diverse supramolecular architectures like interpenetrating polymer networks and organic frameworks.
• Applications span supramolecular adhesives, energy dissipators, and nano-adhesion analysis.
• Significant progress in biomedical applications including drug design, advanced drug delivery systems, DNA detection, tissue engineering, and gene transfection vectors.

Conclusions:

• Multiple hydrogen bonding is a powerful tool for constructing advanced supramolecular materials with tailored properties.
• The field shows great promise for innovative solutions in drug delivery, diagnostics, and regenerative medicine.
• Addressing current challenges will further propel the development and application of these materials.