Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Inflammatory Response01:28

Inflammatory Response

2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunological consequences of senescence in physiology and pathology.

Journal of translational medicine·2026
Same author

A robust direction of arrival estimation method based on the chaotic MUSIC algorithm.

Scientific reports·2026
Same author

Acyl-CoA-binding protein (ACBP): a poor-prognosis biomarker in sepsis and a target for disease mitigation.

Signal transduction and targeted therapy·2026
Same author

2-Methoxystypandrone from <i>Polygonum cuspidatum</i> Rejuvenates Senescence by Reducing Mitochondrial ROS.

Antioxidants (Basel, Switzerland)·2026
Same author

Mitochondrial Integrity as the Gatekeeper of Cardiac Stress Adaptation: Insights From CRIF1 Deficiency.

Korean circulation journal·2026
Same author

Recent Progress in on-Demand Transfer-Enabled Integration of Wavelength-Scale Light Sources.

Nanophotonics (Berlin, Germany)·2026

Related Experiment Video

Updated: Jul 6, 2025

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
07:25

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

1.5K

Mucosal TLR5 activation controls healthspan and longevity.

Jae Sung Lim1,2, Eun Jae Jeon3, Hye Sun Go3

  • 1Department of Biochemistry, Chonnam National University Medical School, Hwasun-gun, Jeonnam-do, 58128, Republic of Korea.

Nature Communications
|January 3, 2024
PubMed
Summary
This summary is machine-generated.

Stimulating toll-like receptor 5 (TLR5) with a fusion protein extended lifespan and improved healthspan in mice. This intervention enhanced immunity, cognition, and prevented age-related diseases, offering a novel strategy for longevity.

More Related Videos

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.4K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.5K

Related Experiment Videos

Last Updated: Jul 6, 2025

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
07:25

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

1.5K
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.4K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.5K

Area of Science:

  • Immunology
  • Gerontology
  • Molecular Biology

Background:

  • Age-related immune decline (immunosenescence) compromises health and increases susceptibility to disease.
  • Therapeutic interventions targeting immune defects are crucial for promoting healthy aging.
  • The immune system's role extends to tissue repair and homeostasis, making its maintenance vital.

Purpose of the Study:

  • To investigate the potential of stimulating toll-like receptor 5 (TLR5) via mucosal delivery to improve healthspan and lifespan.
  • To evaluate the effects of a flagellin-containing fusion protein on age-related physiological decline.
  • To elucidate the mechanisms underlying TLR5-mediated health benefits in aging.

Main Methods:

  • Mucosal administration of a flagellin-containing fusion protein to mice.
  • Assessment of lifespan and various healthspan parameters, including physical, cognitive, and immunological markers.
  • Analysis of intestinal mucosal integrity and immune cell responses, specifically dendritic cells and interleukin-22 (IL-22) secretion.

Main Results:

  • Significant extension of lifespan and enhancement of healthspan in both male and female mice.
  • Improvements observed in hair loss, ocular lens opacity, bone mineral density, stem cell activity, and cognitive function.
  • Delayed thymic involution and prevention of pulmonary lung fibrosis were noted.
  • Enhanced intestinal mucosal integrity through increased TLR5 expression on dendritic cells and elevated IL-22 secretion.

Conclusions:

  • TLR5 stimulation via mucosal delivery of the fusion protein is a viable strategy for extending lifespan and healthspan.
  • The observed benefits are linked to improved mucosal immunity and reduced age-related pathologies.
  • Targeting TLR5 in the mucosal compartment offers a promising therapeutic avenue for promoting longevity and healthy aging.