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Updated: Jul 6, 2025
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
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Egg-sensitised infants have elevated CD4+ effector memory T regulatory cells from birth
Cristina Gamez1,2, Jonatan Leffler1, Sharon Clark1
1Telethon Kids Institute, The University of Western Australia, Nedlands, Western Australia, Australia.
Summary
Early egg sensitization in infants is linked to specific immune cell profiles detectable at birth. These findings offer insights into developing future food allergy prevention strategies.
Area of Science:
- Immunology
- Allergy Research
- Infant Health
Background:
- IgE-mediated sensitization to egg is a common infant issue.
- Mechanisms of early-life egg sensitization are not well understood.
- Sensitization can occur before solid food introduction.
Purpose of the Study:
- To identify unique immune profiles associated with early-life egg sensitization in infants.
- To investigate the presence of these immune profiles at birth.
Main Methods:
- Detailed immune cell phenotyping of peripheral blood mononuclear cells.
- In vitro cytokine response assessment after allergen-specific and non-specific stimulation.
- Comparison of immune profiles in infants with and without early egg sensitization, including cord blood analysis.
Main Results:
- Infants with egg sensitization showed increased CD4+ T regulatory cells (Treg), CD4+ effector memory (EM) Treg, and FcεR1 expression on basophils.
- Elevated CD4+ EM Treg profiles were observed in cord blood of sensitized infants.
- A Th2-skewed immune system, expanded basophils, and reduced CD4- T cells were noted in sensitized infants.
Conclusions:
- Immunological markers for egg sensitization are present in infants at 4-6 months and at birth.
- Understanding these early immune mechanisms is crucial for developing food allergy prevention strategies.
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