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Updated: Jun 23, 2026
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Myocardial Infarction and Functional Outcome Assessment in Pigs
Published on: April 25, 2014
Effect of labetalol on indices of myocardial necrosis in patients with suspected acute infarction
European Heart Journal
|January 1, 1987
Summary
Labetalol, a combined alpha and beta blocker, did not limit infarct size in patients with suspected myocardial infarction. The drug caused greater release of CKMB enzyme, indicating it is not recommended for routine use.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Combined alpha and beta blockade is explored for limiting infarct size.
- Labetalol is investigated for its potential cardioprotective effects in acute myocardial infarction.
Purpose of the Study:
- To evaluate the efficacy of labetalol in reducing infarct size in patients with suspected myocardial infarction.
- To assess the impact of labetalol on cardiac enzyme release and hemodynamic parameters.
Main Methods:
- A randomized controlled trial was conducted with 166 suitable patients admitted to a cardiac care unit.
- Patients received either labetalol (intravenous followed by oral) or conventional therapy.
- Dosing was adjusted to maintain systolic blood pressure between 100-120 mmHg.
Main Results:
- Labetalol lowered blood pressure and heart rate during intravenous administration.
- Significantly greater release of creatine kinase-MB (CKMB) enzyme was observed in the labetalol group.
- No significant differences were noted in R wave scores or ejection fraction between groups.
Conclusions:
- Low doses of labetalol are typically required for acute myocardial infarction patients.
- Labetalol is not recommended for routine treatment of normotensive patients with suspected myocardial infarction.
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