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Elevated plasma matrix metalloproteinases associate with Mycobacterium tuberculosis blood stream infection and

N F Walker1,2,3, C Schutz2,4, A Ward4

  • 1Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, United Kingdom.

Medrxiv : the Preprint Server for Health Sciences
|January 3, 2024
PubMed

Insights

Mortality from HIV-associated tuberculosis (HIV-TB) is high. Biomarkers like MMP-8 and PIIINP indicate disease severity and predict mortality in hospitalized patients with HIV-TB.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Biochemistry

Background:

  • Mortality from HIV-associated tuberculosis (HIV-TB) remains high, especially in hospitalized patients.
  • Understanding the host response in HIV-TB is crucial for developing effective treatments.

Approach:

  • Investigated plasma matrix metalloproteinases (MMP) and matrix-derived biomarkers in 433 hospitalized individuals with HIV and TB symptoms.
  • Assessed biomarkers in relation to TB diagnosis, mortality, and Mycobacterium tuberculosis (Mtb) bloodstream infection (BSI).

Key Points:

  • MMP-8 was elevated in confirmed TB and Mtb-BSI, correlating with extracellular matrix breakdown.
  • Baseline MMP-3, -7, -8, -10, and procollagen III N-terminal propeptide (PIIINP) were associated with Mtb-BSI and 12-week mortality.

Conclusions:

  • MMP dysregulation is implicated in the pathophysiology of advanced HIV-TB.
  • These biomarkers may aid in diagnosing and prognosing HIV-TB.
  • MMP inhibition presents a potential host-directed therapeutic strategy for HIV-TB.
Keywords:
HIVTuberculosismatrix metalloproteinasemortality

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