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Related Experiment Video

Updated: Jul 6, 2025

Author Spotlight: Optimizing Micro-Drive Systems for Precise Electrode Positioning in Marmoset

Author Spotlight: Optimizing Micro-Drive Systems for Precise Electrode Positioning in Marmoset

Published on: August 4, 2023

Acute Neuropixels recordings in the marmoset monkey.

Nicholas M Dotson¹, Zachary W Davis^1,2, Patrick Jendritza¹

¹The Salk Institute for Biological Studies, La Jolla, California.

Biorxiv : the Preprint Server for Biology

|January 3, 2024

Summary

We developed a novel method for acute Neuropixels recordings in marmosets, enabling detailed study of brain activity across cortical layers. This technique facilitates long-term neural recordings in a unique animal model for systems neuroscience.

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Area of Science:

Neuroscience
Systems Neuroscience
Computational Neuroscience

Background:

High-density neural probes like Neuropixels offer insights into neural population dynamics and behavior.
Marmoset monkeys possess a smooth cortex ideal for perpendicular neural recordings and laminar computation studies.

Approach:

A novel surgical method for acute Neuropixels recordings in the common marmoset (Callithrix jacchus).
Utilizes an artificial silicon-based dura for improved cortical access, perpendicular probe insertion, and compatibility with optical techniques.
The technique supports repeated acute penetrations over months, with potential for year-long recordings after minimal maintenance.

Key Points:

Enables recording of hundreds of single neurons across cortical layers.
Facilitates precise investigation of laminar computations and their behavioral relevance.
Compatible with Neuropixels probes, semi-chronic microdrives, and wireless recording systems.

Conclusions:

This method provides a robust platform for advanced neuroscience research in marmosets.
It opens new avenues for understanding neural circuits and brain function at a laminar level.
The technique is adaptable for various experimental paradigms, including combined optical and electrophysiological recordings.