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Related Experiment Video

Updated: Jul 6, 2025

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

Stable Cortical Body Maps Before and After Arm Amputation.

Hunter R Schone^1,2,3,4, Roni O Maimon Mor^1,5,6, Mathew Kollamkulam^1,7

¹Institute of Cognitive Neuroscience, University College London, London, UK.

Biorxiv : the Preprint Server for Biology

|January 3, 2024

Summary

This summary is machine-generated.

Adult brain reorganization after arm amputation is debated. New research shows stable cortical representations of hands and lips, suggesting amputation does not cause large-scale brain changes.

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Last Updated: Jul 6, 2025

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

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Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

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Published on: July 10, 2019

Area of Science:

Neuroscience
Neuroplasticity
Brain Imaging

Background:

The adult brain's ability to reorganize (neuroplasticity) after injury, like amputation, is a key area of research.
Previous studies, including animal models, suggested significant cortical reorganization following limb loss.

Conclusions:

Arm amputation does not induce widespread cortical reorganization in the adult brain.
The adult brain maintains stable neural representations despite limb loss.
This study provides critical evidence against large-scale cortical reorganization post-amputation.