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Identification of cuproptosis-related genes and immune infiltration in dilated cardiomyopathy

Yixuan Lin1, Kaicong Chen1, Jinhua Guo2

  • 1Department of Cardiology, The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan, China.

International Journal of Cardiology
|January 3, 2024
PubMed

Insights

Six novel genes linked to cuproptosis were identified as potential diagnostic biomarkers for dilated cardiomyopathy (DCM). Their expression correlates with immune cell infiltration, suggesting a role for cuproptosis in DCM

Area of Science:

  • Cardiology
  • Molecular Biology
  • Genetics

Background:

  • Dilated cardiomyopathy (DCM) is a primary cause of heart failure.
  • The role of cuproptosis in DCM pathogenesis remains largely unexplored.
  • This study investigates cuproptosis-related genes as potential diagnostic markers for DCM.

Purpose of the Study:

  • To identify cuproptosis-related genes as diagnostic biomarkers for DCM.
  • To explore the association between these genes, immune infiltration, and drug targets in cardiac tissue.
  • To elucidate the potential role of cuproptosis in DCM pathophysiology.

Main Methods:

  • Gene expression data from non-failure (NF) and DCM samples were analyzed.
  • Cuproptosis scores were calculated using single-sample gene set enrichment analysis (ssGSEA).
  • Weighted gene co-expression network analysis (WGCNA), Random Forest, and LASSO were employed to identify signature genes.
  • Immune cell infiltration and regulatory networks were analyzed using ssGSEA and Cytoscape.

Main Results:

  • Eight gene modules were identified via WGCNA, with 'MEblue' significantly associated with cuproptosis and DCM.
  • A diagnostic model comprising six signature genes (SEPTIN1, CLEC11A, ISG15, P3H3, SDSL, and INKA1) was established.
  • Significant differences in immune cell infiltration were observed between DCM and NF groups.
  • Regulatory networks for mRNA-miRNA-lncRNA and chemical-drug interactions were constructed based on the signature genes.

Conclusions:

  • Six genes (SEPTIN1, CLEC11A, ISG15, P3H3, SDSL, and INKA1) were identified as novel diagnostic biomarkers for DCM.
  • The expression of these genes is linked to immune cell infiltration in DCM.
  • Cuproptosis may play a role in the immune regulation of dilated cardiomyopathy.
Abstract

Keywords:
BiomarkerCuproptosisDilated cardiomyopathyImmune infiltrationMachine learning

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