Recent bio-applications of covalent organic framework-based nanomaterials
Jun Guo1, Shuyue Kong1,2, Ye Lian1
1State Key Laboratory of Separation Membranes and Membrane Processes, School of Chemistry, Tiangong University, Tianjin 300387, China. junguo@tiangong.edu.cn.
Chemical Communications (Cambridge, England)
|January 3, 2024
Summary
Covalent organic frameworks (COFs) are novel biomaterials with unique properties for diverse applications. This review highlights their use in drug delivery, therapy, and bioimaging, alongside future research directions.
Area of Science:
- Materials Science
- Biomedical Engineering
- Organic Chemistry
Background:
- Covalent organic frameworks (COFs) emerged in 2005 as a new class of functional organic materials.
- COFs possess desirable properties such as ultralight weight, high surface area, ordered channels, and tunable functional groups.
- Their well-defined crystalline structures make them promising for various biomedical applications.
Purpose of the Study:
- To comprehensively review the applications of COF-based biomaterials.
- To introduce the use of COFs in drug loading and delivery, photodynamic therapy, photothermal therapy, and bioimaging.
- To discuss current challenges and future prospects for COFs in multifunctional bioplatforms.
Main Methods:
- Literature review of COF applications in biomaterials.
- Synthesis and characterization of COFs for biomedical purposes (implied).
- Analysis of COF properties relevant to biological systems.
Main Results:
- COFs demonstrate significant potential in drug loading and delivery systems.
- COF-based materials show promise for photodynamic and photothermal therapies.
- COFs are applicable in bioimaging due to their structural and optical properties.
Conclusions:
- COFs represent a versatile platform for developing advanced biomaterials.
- Further research is needed to overcome existing challenges and fully realize the potential of COFs.
- This review provides guidance for future research on COFs as multifunctional bioplatforms.
