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Core-shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management.

Rui Wang^1,2, Yanfang Sun³, Han Wang⁴

¹School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China. ghjiang_cn@zstu.edu.cn.

Journal of Materials Chemistry. B

|January 3, 2024

Summary

A novel microneedle patch delivers drugs transdermally for hyperuricemia treatment. This patch releases allopurinol and urate oxidase nanoparticles to effectively lower serum uric acid levels for extended periods.

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Area of Science:

Biomaterials Science
Nanotechnology
Pharmacology

Background:

Hyperuricemia management requires effective non-oral drug delivery platforms.
Transdermal drug delivery offers a promising alternative for sustained therapeutic effects.
Current treatments for hyperuricemia have limitations necessitating innovative approaches.

Purpose of the Study:

To design and fabricate a core-shell microneedle patch for transdermal hyperuricemia treatment.
To achieve programmed release of allopurinol and urate oxidase nanoparticles for sustained serum uric acid regulation.
To evaluate the *in vivo* efficacy and safety of the microneedle patch in managing hyperuricemia.

Main Methods:

Fabrication of core-shell microneedles using a three-step casting method.
Encapsulation of allopurinol in carboxymethyl cellulose (shell) and urate oxidase-calcium peroxide nanoparticles in polyvinylpyrrolidone (core).
In vitro and *in vivo* evaluation of drug release kinetics, serum uric acid reduction, and safety parameters.

Main Results:

The microneedle patch demonstrated a dual-drug release mechanism for sustained serum uric acid reduction.
Serum uric acid levels were normalized within 3 hours and maintained for 12 hours post-application.
No significant changes in creatinine, blood urea nitrogen, or liver enzyme activities were observed, indicating good safety.

Conclusions:

The developed core-shell microneedle patch is an effective transdermal system for hyperuricemia management.
Programmed release of allopurinol and urate oxidase nanoparticles ensures prolonged normouricemia.
This innovative approach mitigates risks of liver and kidney damage associated with hyperuricemia treatment.