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Updated: Jul 6, 2025

Thermal Measurement Techniques in Analytical Microfluidic Devices

Thermal Measurement Techniques in Analytical Microfluidic Devices

Published on: June 3, 2015

A portable microfluidic device for thermally controlled granular sample manipulation.

Kailiang Zhang¹, Wei Xiang¹, Na Jia¹

¹College of Mechanical and Electrical Engineering, Northeast Forestry University, Hexing Road 26, Harbin, Heilongjiang, PR China 150040. xiezhijie111@sina.com.

|January 3, 2024

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This study introduces a portable microfluidic device using thermal fields for precise particle manipulation, including focusing, migration, and droplet release. The device enables convenient sample detection and release for various applications.

Area of Science:

Microfluidics
Thermal Engineering
Biotechnology

Background:

Effective manipulation of granular samples is crucial for applications like point-of-care testing and cargo delivery.
Existing methods often lack portability and real-time visualization, limiting their use in diverse environments.

Purpose of the Study:

To develop and demonstrate a portable microfluidic device for controlled particle manipulation using thermal fields.
To showcase the device's capabilities in particle focusing, single-particle migration, and double-emulsion droplet release.
To enable convenient and visualizable sample detection and manipulation in various settings.

Main Methods:

A portable microfluidic device integrating a microfluidic chip, microcontroller, built-in microscope, and smartphone.

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Utilized five microheaters to generate thermal buoyancy flow and thermocapillary effects for particle manipulation.

Demonstrated particle focusing, single-particle migration, and double-emulsion droplet release by controlling microheater voltages.

Main Results:

Achieved controlled focusing of multiple particles (silica particles, yeast cells) with efficiency tunable via voltage control.
Demonstrated precise single-particle migration along predetermined trajectories and speeds.
Successfully manipulated double-emulsion droplet release, with adjustable core release speed.

Conclusions:

The portable microfluidic device effectively demonstrates granular manipulation through thermal fields.
The device offers multifunctionality for particle focusing, migration, and droplet release.
This technology shows promise for applications in analytical detection, microrobot actuation, and cargo release.