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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

[Immunotherapy against gliomas].

Katharina Sahm^1,2, Tobias Weiss³

¹Neurologische Klinik, Medizinische Fakultät Mannheim, MCTN, Universität Heidelberg, Mannheim, Deutschland.

|January 3, 2024

Summary

Immunotherapy for gliomas shows promise but requires further research. While some approaches like anti-PD1 antibodies have not improved survival, others like vaccinations and cell therapy show potential in early studies.

Keywords:

Brain tumor vaccines Cell therapy Cytokines Immune checkpoint inhibitors Viral treatment

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Area of Science:

Neuro-oncology
Immunology
Cancer research

Context:

Gliomas are the most common malignant adult brain tumors with a poor prognosis despite standard treatments.
Advances in cancer immunology have spurred the development of immunotherapeutic strategies for gliomas.
Existing treatments including surgery, radiation, and chemotherapy offer limited efficacy.

Purpose:

To review current immunotherapeutic strategies for gliomas.
To highlight the benefits, drawbacks, and challenges of these approaches.
To summarize ongoing clinical trials in Germany and surrounding regions.

Summary:

Early trials of anti-PD1 immune checkpoint inhibitors, viral treatments, and EGFRvIII peptide vaccines in glioblastoma did not improve survival.
Multivalent or driver mutation-based vaccinations, cytokine therapy, and cell therapy show a strong scientific basis with promising safety and tumor effects in initial studies.
Significant knowledge gaps persist regarding the mechanisms of action and resistance for glioma immunotherapies.

Impact:

Current immunotherapies for gliomas should be confined to clinical trials.
Translational research is crucial for understanding and overcoming immunotherapy resistance.
Further investigation is needed to develop more effective glioma treatments.