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Association between doxycycline use and long-term functioning in patients with schizophrenia
Lot D de Witte1, Thomas Munk Laursen2, Cheryl M Corcoran3
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Brain, Behavior, and Immunity
|January 3, 2024
Summary
Doxycycline, a brain-penetrant antibiotic, was associated with a lower incidence of disability pension in schizophrenia patients. This suggests potential long-term neuroprotective benefits and improved functioning for individuals with schizophrenia.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Schizophrenia treatment often focuses on symptom management, with limited options for improving long-term functioning.
- Brain-penetrant tetracyclines like minocycline and doxycycline show preclinical promise for schizophrenia.
- The long-term impact of doxycycline on schizophrenia patient outcomes remains under-investigated.
Purpose of the Study:
- To investigate if doxycycline prescription redemption in schizophrenia patients correlates with a reduced incidence of disability pension.
- To assess doxycycline's association with long-term functional outcomes in schizophrenia.
Main Methods:
- Population-based cohort study utilizing Danish registry data.
- Survival analysis with time-varying covariates to compare disability pension incidence.
- Adjusted for age, sex, calendar year, parental psychiatric history, and education level.
Main Results:
- 11,157 schizophrenia patients were analyzed; 718 exposed to doxycycline.
- Doxycycline exposure was linked to a significantly lower incidence of disability pension compared to no tetracycline use (IRR 0.68).
- Doxycycline use also showed a significantly lower disability pension rate compared to non-brain-penetrant tetracyclines (IRR 0.69).
Conclusions:
- Doxycycline exposure in schizophrenia patients is associated with a reduced incidence of disability pension.
- These findings support further research into doxycycline's potential long-term neuroprotective effects.
- Doxycycline may positively influence long-term functioning in schizophrenia patients.
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