Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

46.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early antiretroviral therapy shapes the immunometabolic landscape without reducing the intact HIV reservoir.

The Journal of infection·2026
Same author

Systemic lupus erythematosus extends beyond a type I interferonopathy, as demonstrated by NET-activated monocytes.

Clinical and translational medicine·2026
Same author

Effector-host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation.

Nature microbiology·2026
Same author

Resident CD49a<sup>+</sup>CD103<sup>+</sup>NKG2C<sup>+</sup> NK cells restrict HIV infection in human lymphoid tissue explants.

Science advances·2026
Same author

Cervical mucosal inflammation expands functional polymorphonuclear myeloid-derived suppressor cells.

Mucosal immunology·2025
Same author

High-Dimensional Immunophenotyping of Post-COVID-19 and Post-Influenza Patients Reveals Persistent and Specific Immune Signatures After Acute Respiratory Infection.

Journal of medical virology·2025

Related Experiment Video

Updated: Jul 6, 2025

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.4K

Targeting HIV persistence in the tissue.

Daan K J Pieren1, Aleix Benítez-Martínez, Meritxell Genescà

  • 1Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.

Current Opinion in HIV and AIDS
|January 3, 2024
PubMed
Summary

Understanding the complex HIV reservoir in tissues is key to eliminating viral persistence. New research explores tissue-specific persistence and novel therapeutic strategies for an HIV cure.

More Related Videos

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
07:21

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

21.1K
High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
07:18

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

5.8K

Related Experiment Videos

Last Updated: Jul 6, 2025

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.4K
Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
07:21

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

21.1K
High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
07:18

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

5.8K

Area of Science:

  • Virology and Immunology
  • HIV/AIDS Research
  • Reservoir Persistence

Background:

  • The HIV reservoir in tissues presents a major obstacle to HIV cure due to its complex nature and distribution.
  • Tissue-specific latency and viral persistence lead to significant reservoir heterogeneity.
  • Eliminating these reservoirs requires strategies tailored to their unique cellular and anatomical characteristics.

Conclusions:

  • Targeting tissue reservoirs is a critical, albeit complex, step towards an HIV cure.
  • Combinatorial strategies, especially early in infection, are essential for impacting initial reservoirs.
  • Reactivating and eliminating multiple long-lived reservoirs throughout the body is crucial for achieving a functional cure.