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Causal relationship between gut microbiota and glioblastoma: a two-sample Mendelian randomization study
Chao Ju1,2, Yanjing Chen2, Longtao Yang2
1Department of Radiology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China.
Journal of Cancer
|January 3, 2024
Summary
This study used Mendelian randomization to investigate the gut microbiota
Area of Science:
- Microbiome research
- Oncology
- Genetics
Background:
- Observational studies suggest a link between gut microbiota and glioblastoma.
- Causal relationship between gut microbiota and glioblastoma remains unclear.
Purpose of the Study:
- To investigate the causal relationship between gut microbiota and glioblastoma using a two-sample Mendelian randomization study.
Main Methods:
- Employed data from MiBioGen and FinnGen consortiums.
- Utilized various Mendelian randomization methods including IVW, WME, and MR-Egger.
- Performed reverse Mendelian randomization analysis.
Main Results:
- Identified seven causal relationships between gut microbiota and glioblastoma.
- No significant causal effect of glioblastoma on gut microbiota was found.
- No significant heterogeneity or horizontal pleiotropy observed.
Conclusions:
- A causal association exists between gut microbiota and glioblastoma.
- Further research is needed to understand the underlying mechanisms.
