Lack of effect of verapamil on urinary prostaglandin E2 excretion in the rabbit

The effects of verapamil on renal function, the renin-angiotensin-aldosterone system and renal prostaglandin E2 were investigated in the rabbit. Verapamil, administered with rate-controlled osmotic pumps, showed no significant effects on plasma renin activity, plasma aldosterone and urinary prostaglandin E2 excretion. There were marked rises in the glomerular filtration rate and calcium excretion but no significant change in slat and water excretion was observed with verapamil. It is concluded that the hypotensive response to verapamil is unrelated to the renin-angiotensin-aldosterone system and to renal prostaglandin E2.