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Bradykinin inhibits a slow spike afterhyperpolarization in visceral sensory neurons
European Journal of Pharmacology
|December 2, 1986
Abstract:
Intracellular recordings were made from visceral sensory neurons in vitro. Bradykinin (BK) depressed a slow Ca2+-activated K+-dependent (KCa) spike afterhyperpolarization (AHPs) in the range of 0.2-1 nM. BK did not affect the fast KCa spike afterhyperpolarization preceding the AHPs or the action potential waveform. Indomethacin pretreatment abolished the BK effect. These results indicate that BK can influence the excitability of vagal afferent neurons.