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Updated: Jul 6, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Performance and explainability of feature selection-boosted tree-based classifiers for COVID-19 detection
Jesús Rufino1, Juan Marcos Ramírez1, Jose Aguilar1,2,3
1IMDEA Networks Institute, 28918, Madrid, Spain.
This study introduces a machine learning method using feature selection to accurately predict COVID-19 cases from self-reported data, enhancing public health surveillance. The approach considers diverse factors beyond symptoms for improved detection.
Area of Science:
- Computational epidemiology
- Machine learning applications in public health
- Infectious disease modeling
Background:
- Self-reported data offers a vast resource for tracking infectious diseases like COVID-19.
- Previous methods often used limited symptom sets, potentially missing broader influencing factors.
- The University of Maryland Global COVID-19 Trends and Impact Survey (UMD-CTIS) collected extensive relevant information.
Purpose of the Study:
- To develop and evaluate a machine learning methodology for predicting COVID-19-positive cases using comprehensive self-reported data.
- To enhance the explainability and performance of predictive models through feature selection.
- To identify key factors contributing to COVID-19 spread across different countries and time periods.
Main Methods:
- Employed recursive feature elimination (RFE) for feature selection to optimize model input.
- Utilized tree-based supervised machine learning classifiers: Random Forests (RF), Light Gradient Boosting (LGB), and Extreme Gradient Boosting (XGB).
- Evaluated model performance using metrics like F1-score, sensitivity, specificity, precision, ROC, and AUC across Brazil, Canada, Japan, and South Africa for 2020-2021.
Main Results:
- The methodology successfully predicted COVID-19 cases with high accuracy across diverse countries and timeframes.
- Feature selection effectively reduced input variables without compromising detection performance.
- Shapley values and feature importance analyses provided insights into the drivers of COVID-19 incidence.
Conclusions:
- Machine learning models, enhanced by feature selection and broad data inputs, offer a robust approach for COVID-19 prediction.
- The methodology demonstrates the utility of diverse data sources, including community information and vaccination status, for epidemiological surveillance.
- Explainability analysis confirmed the model's ability to identify significant predictors of COVID-19 spread.
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