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Levetiracetam: A Potent Sword against Microglia Polarization in Gliomas

Xiaoteng Cui1,2, Qixue Wang1,2, Xiaomin Liu3

  • 1Laboratory of Neuro-oncology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, P.R China.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|January 3, 2024
PubMed

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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
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