Modification of vestibular-induced pause neuron firing during anesthesia and light sleep

Anatomic and electrophysiologic evidence suggests there is a vestibular input to eye movement-related pause neurons in the midline of the pontine reticular formation of the cat. The present investigation sought to explore the functional significance of this vestibular drive by examining pause neuron response to horizontal rotational stimulation as cats were anesthetized with halothane or went into natural light sleep. Anesthesia unmasks the vestibular input to pause neurons in that during anesthesia, pause neurons continue to fire but their firing rate is modulated by vestibular stimulation. The particular response patterns of pause neurons to anesthesia are not uniform. We suggest that the results observed could be explained if pause neurons received input from both vestibular nuclei, either directly or possibly via the prepositus hypoglossi.