Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphologic changes in nerve cell bodies induced by experimental graded nerve compression.

L B Dahlin, C Nordborg, G Lundborg

    Experimental Neurology
    |March 1, 1987
    PubMed
    Summary

    Experimental nerve fiber compression, even at low pressures, causes significant changes in nerve cell bodies. These findings in rabbits mirror human carpal tunnel syndrome, suggesting a link to axonal transport disruption.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ulnar nerve dislocation in ulnar nerve entrapment at the elbow. Influence on surgical outcome.

    Hand surgery & rehabilitation·2021
    Same author

    Association between HbA<sub>1c</sub> and peripheral neuropathy in a 10-year follow-up study of people with normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes.

    Diabetic medicine : a journal of the British Diabetic Association·2017
    Same author

    Congenital thumb anomalies and the consequences for daily life: patients' long-term experience after corrective surgery. A qualitative study.

    Disability and rehabilitation·2016
    Same author

    One-year results of needle fasciotomy and collagenase injection in treatment of Dupuytren's contracture: A two-centre prospective randomized clinical trial.

    The Journal of hand surgery, European volume·2015
    Same author

    Long-term results of syndactyly correction by the trilobed flap technique focusing on hand function and quality of life.

    The Journal of hand surgery, European volume·2015
    Same author

    Professor Nils Carstam, MD, PhD, 13 September 1913-28 May 2014.

    The Journal of hand surgery, European volume·2014

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Experimental Pathology

    Background:

    • Nerve fiber compression is implicated in conditions like carpal tunnel syndrome.
    • Understanding the cellular response to compression is crucial for neurological research.

    Purpose of the Study:

    • To investigate the morphological effects of experimental nerve fiber compression on nerve cell bodies.
    • To correlate these changes with potential axonal transport disturbances.

    Main Methods:

    • Rabbit cervical vagus nerves were subjected to crush or compression (0-400 mm Hg) for 2 hours.
    • Morphometric analysis and light microscopy of nodose ganglion cells were performed 7 days post-injury.

    Main Results:

    • Compression and crush injuries led to decreased cell profile area and nuclear volume density.

    Related Experiment Videos

  • Nucleus migration and Nissl substance dispersion were observed in nerve cell bodies after compression.
  • Sham compression showed minimal cellular changes compared to controls.

    • Conclusions:

    • Nerve fiber compression induces reactive changes in nerve cell bodies, even at low pressures.
    • These changes resemble those seen in human carpal tunnel syndrome.
    • Cellular alterations may result from disruptions in fast and retrograde axonal transport.