Cardiometabolic index is associated with increased depression: A population-based study
Lulu Cheng1, Qinggang Wu2, Siyu Wang3
1College of Acupuncture-Moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei 230012, China; Graduate School, Wuhan Sports University, Wuhan 430079, China.
Journal of Affective Disorders
|January 3, 2024
Summary
The Cardiometabolic Index (CMI) is linked to a higher likelihood of depression symptoms in US adults. Higher CMI levels indicate an increased risk for depression, particularly in individuals with hypertension.
Area of Science:
- Cardiovascular Health
- Metabolic Syndrome
- Psychiatric Epidemiology
Background:
- Depression is a complex psychiatric disorder influenced by lipid metabolism.
- Cardiometabolic Index (CMI) integrates lipid profiles (triglyceride/HDL-C) and obesity indicators (waist-to-height ratio).
- Understanding novel biomarkers for depression risk is crucial.
Purpose of the Study:
- To investigate the correlation between the Cardiometabolic Index (CMI) and the incidence of depression.
- To analyze the association using a large, representative US population dataset.
Main Methods:
- Utilized National Health and Nutrition Examination Survey (NHANES) data (2011-2018).
- Employed multivariate logistic regression, sensitivity analysis, and smooth curve fitting.
- Conducted subgroup analyses and interaction tests to assess population stability.
Main Results:
- A positive association was observed between CMI and depression in 7,229 participants (>20 years).
- Each unit increase in CMI correlated with a 36% higher likelihood of depression symptoms.
- The highest CMI quartile showed a 62% increased depression risk compared to the lowest quartile, notably in hypertensive individuals.
Conclusions:
- CMI is significantly associated with increased depression likelihood and higher PHQ-9 scores in US adults.
- The findings suggest CMI as a potential indicator for depression risk.
- Further large-scale prospective studies are warranted to confirm CMI's role in depression.
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