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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

180
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
180
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

244
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

240
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
240
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

332
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
332

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Related Experiment Video

Updated: Jul 6, 2025

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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Natural products in anti-tuberculosis host-directed therapy.

Xuejiao Huang1, Douglas B Lowrie1, Xiao-Yong Fan1

  • 1Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai 201508, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 3, 2024
PubMed
Summary

Host-directed therapy (HDT) using natural products offers a promising, cost-effective strategy to combat tuberculosis (TB) by modulating the host immune response, complementing traditional chemotherapy for better treatment outcomes.

Keywords:
Adjunctive therapyHost-directed therapyImmune responseNatural productTuberculosis

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Area of Science:

  • Immunology
  • Pharmacology
  • Natural Products Research

Background:

  • Tuberculosis (TB) progression is linked to host immunity, suggesting chemotherapy alone may be insufficient for eradication of Mycobacterium tuberculosis.
  • Host-directed therapy (HDT) aims to bolster host defenses, reduce inflammation, and improve treatment efficacy.
  • Current HDT candidates face challenges with side effects and cost.

Purpose of the Study:

  • To review anti-TB immunology and HDT principles.
  • To explore the rationale and challenges of developing natural product-based HDT.
  • To summarize current clinical and preclinical evaluations of HDT agents.

Main Methods:

  • Literature review of anti-TB immunology.
  • Analysis of host-directed therapy concepts and challenges.
  • Survey of natural products as potential immune modulators for TB.

Main Results:

  • Natural products present a viable alternative to synthetic HDT drugs due to their lower cost and gentler immune modulation.
  • Natural products can mitigate side effects and immunopathological damage associated with conventional treatments.
  • Ongoing research is evaluating various natural products in preclinical and clinical settings for TB treatment.

Conclusions:

  • Natural product-based HDT holds significant potential to enhance tuberculosis treatment efficacy and overcome limitations of current approaches.
  • Further research and target-based screening are crucial for accelerating the discovery of novel TB drugs.
  • Integrating natural products into HDT strategies could lead to more accessible and effective TB therapies.