Are the serum delta neutrophil index and systemic inflammatory index useful as predictive parameters for preeclampsia...

Area of Science:

• Reproductive Medicine
• Immunology
• Hematology

Background:

• Preeclampsia and HELLP syndrome are serious pregnancy complications with significant maternal and fetal risks.
• The role of inflammation in the pathogenesis of these conditions is increasingly recognized.
• Diagnostic tools for preeclampsia and HELLP syndrome require refinement for earlier and more accurate detection.

Purpose of the Study:

• To evaluate the auxiliary diagnostic role of serum delta neutrophil index (DNI) and other inflammatory markers in preeclampsia and HELLP syndrome.
• To investigate the contribution of inflammation to the pathogenesis of preeclampsia and HELLP syndrome.

Main Methods:

• A comparative study involving 121 pregnant women: 52 with preeclampsia, 19 with HELLP syndrome, and 50 healthy controls.
• Collection and comparison of demographic data, hematological, biochemical parameters, and inflammatory markers including serum DNI.
• Statistical analysis to compare inflammatory markers between the study groups.

Main Results:

• The HELLP syndrome group showed significant differences in neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and DNI compared to both preeclampsia and control groups.
• The monocyte-to-lymphocyte ratio differed between the preeclampsia group and both other groups.
• No significant differences were observed in the systemic inflammatory index across all three groups.

Conclusions:

• Maternal serum DNI, when used with other biochemical parameters, can serve as an auxiliary marker for diagnosing preeclampsia and HELLP syndrome.
• These findings support the hypothesis that inflammation plays a role in the pathogenesis of preeclampsia and HELLP syndrome.