Related Experiment Video
Updated: Jul 6, 2025
08:24
Multi-Photon Laser Ablation of Cytoplasmic Microtubule Organizing Centers in Mouse Oocytes
Published on: November 11, 2022
1.7K
Assisted oocyte activation.
Ceska Gynekologie
|January 3, 2024
Summary
Assisted oocyte activation, using calcium ion donors, effectively improves in vitro fertilization rates. Studies show this method is safe for embryonic, fetal, and postnatal development, with no negative psychosomatic impact on children.
Area of Science:
- Reproductive biology
- Assisted reproductive technology
Background:
- Assisted oocyte activation (AOA) is increasingly studied to enhance in vitro fertilization (IVF).
- Insufficient oocyte activation can impair fertilization via conventional or intracytoplasmic sperm injection (ICSI) methods.
- This is often due to issues with sperm/oocyte enzymatic equipment or the activation cascade.
Purpose of the Study:
- To review current knowledge on AOA and its effects on IVF.
- To evaluate the impact of AOA on embryonic, fetal, and postnatal development.
Main Methods:
- Literature review of Web of Science, PubMed/Medline, and Scopus databases.
- Analysis of existing data and authors' clinical experience.
Main Results:
- AOA using calcium ion donors is an effective method for achieving fertilization.
- Meta-analyses indicate no adverse effects on embryonic, fetal, or postnatal development.
- No negative impact on the psychosomatic development of children conceived via AOA was found.
Conclusions:
- Assisted oocyte activation is a safe and effective technique to improve IVF outcomes.
- The method supports healthy development from embryo to postnatal stages.
